LS 2

梁 珊珊(Shanshan Liang)



The Key Laboratory of biomarker high throughput screening and target translation of breast and gastrointestinal tumor


[専門] 腫瘍学


  1. Fang Y#, Liang S#, Gao  J, Wang Z , Li C , Wang R, Yu W. Extracellular matrix stiffness mediates radiosensitivity in a 3D nasopharyngeal carcinoma model. Cancer Cell Int 22(1): 364 (2022). (# Equal Contribution) doi: 10.1186/s12935-022-02787-5. New!!
  2. Fang Y, Zhang L, Wang Z, Wang R*, Liang S*. Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis. Front Pharmacol 13: 969709 (2022). (* Corresponding author) doi: 10.3389/fphar.2022.969709. eCollection 2022. New!!
  3. Li H#, Wang Z#, Liang S#, Liu Q, Wang P, Cai L, Wang R. Radiation induces epithelial to mesenchymal transition via upregulation of PD-L1 in nasopharyngeal carcinoma cell. Trans Cancer Res 10(1): 372-381 (2021) # Equal contribution doi: 10.21037/tcr-20-1899. 
  4. Li H#, Liu Q#, Liang S#, Yao P, Lv J, Wang G, Tang R, Zhao T, Li J, Xu L, Ma L, Wang R. Circulating tumor cells and neutrophil-lymphocyte ratio are predictive markers for metastatic colorectal cancer patients.  Trans Cancer Res 10(1): 288-297 (2021) # Equal contribution doi: 10.21037/tcr-20-2032. 
  5. Liu Q#, Fang S#Liang S#, Lv J, Wang G, Tang R, Ji X, Zhao T, Li J, Xu L, Ma L, Wang R, Li H. The prognostic role of a combined fibrinogen and inflammation-based index in patients with metastatic breast cancer. Trans Cancer Res 9(11): 7065-7078 (2020) # Equal contribution doi: 10.21037/tcr-20-2157. 
  6. Sun Y, Chen X, Zhou Y, Qiu S, Wu Y, Xie M, Zhu G, Liang S, Li H, Zhou D, Ju Z, Wang F, Han F, Wang Z, Wang R. Metformin reverses the drug resistance of cisplatin in irradiated CNE-1 human nasopharyngeal carcinoma cells through PECAM-1 mediated MRPs down-regulation. Int J Med Sci 7(16): 2416–2426 (2020).  doi: 10.7150/ijms.48635. 
  7. Liang S, Takahashi H, Hirose T, Kuramitsu Y, Hatakeyama S, Wang R, Yoshiyama H, Hamada J, Iizasa H. NONO is a negative regulator of SOX2 promoter. Cancer Genom Proteom 17(4):359-367 (2020). doi: 10.21873/cgp.20195. 
  8. Sakata K, Maeda K, Sakurai N, Liang S, Nakazawa S, Yanagihara K, Kubo T, Yoshiyama H, Kitagawa Y, Hamada J*, Iizasa H*. ADAR2 regulates malignant behavior in mesothelioma cell lines independent of RNA-editing activity. Anticancer Res 40(3):1307-1314 (2020). doi:10.21873/anticancers.14072. (*Corresponding author)
  9. Liu M, Wang R, Sun X, Liu Y, Wang Z, Yan J, Kong X, Liang S, Liu Q, Zhao T, Ji X, Wang G, Lv W, Li H, Sun M. Prognostic significance of PD-L1 expression on cell-surface vimentin-positive circulating tumor cells in gastric cancer patients. Mol Oncol  doi: 10.1002/1878-0261.12643.
  10. Wang Z, Liu G, Mao J, Xie M, Zhao M, Guo X, Liang S, Li H, Li X, Wang R. IGF-1R inhibition suppresses cell proliferation and increases radiosensitivity in nasopharyngeal carcinoma cells. Mediat Inflamm 2019:1-9 (2019). doi: 10.1155/2019/5497467. 
  11. Nakazawa S, Sakata KI, Liang S, Yoshikawa K, Iizasa H, Tada M, Hamada JI, Kashiwazaki H, Kitagawa Y, Yamazaki Y. Dominant-negative p53 mutant R248Q increases the motile and invasive activities of oral squamous cell carcinoma cells. Biomed Res 40(1):37-49 (2019). doi: 10.2220/biomedres.40.37. 
  12. Wang R, Li H, Guo X, Wang Z, Liang S, Dang C. IGF-I Induces Epithelial-to-Mesenchymal Transition via the IGF-IR-Src-MicroRNA-30a-E-Cadherin Pathway in Nasopharyngeal Carcinoma Cells. Oncol Res. 24(4):225-231 (2016). doi: 10.3727/096504016X14648701447931.
  13. Li H, Zhao T, Ji X, Liang S, Wang Z, Yang Y, Yin J, Wang R.Hyperfibrinogenemia predicts poor prognosis in patients with advanced biliary tract cancer.Tumour Biol 37(3):3535-3542 (2016). doi: 10.1007/s13277-015-4184-6.
  14. Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi, M, Irimura T, Hamada J. Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway. Cancer Lett 339 (1) : 82-92 (2013).
  15. Liang S, Furuhashi M, Nakane R, Nakazawa S, Goudarzi H, Hamada J, Iizasa H*. Isolation and characterization of human breast cancer cells with SOX2 promoter activity. Biochem Biophys Res Commun 437 (2) : 205-211 (2013).


  1. 公益信託岩澤ゑい癌研究助成基金(2014)
  2. 第4回北海道大学遺伝子病制御研究所(IGM)リサーチワークショップ(IGM研究交流会)ポスター部門3位(2013)