Hisashi Iizasa

IIZASA

Hisashi Iizasa

Associate Professor

From Kanagawa prefecture

Postgraduate course of Kanazawa University completed without degree

Doctor of Pharmacy

Distinguished Professor (Zhongshan affiliated hospital of Dalian university, China, September 2015-)

Specializes RNA, cancer and EB virus

Hobby is reading and the whole music

iizasah (A) med.shimane-u.ac.jp   (A) change to @

 

 Main Papers

  1. Liang S, Takahashi H, Hirose T, Kuramitsu Y, Hatakeyama S, Wang R, Yoshiyama H, Hamada J*, Iizasa H*. NONO is a negative regulator of SOX2 promoter. Cancer Genom Proteom 17(4):359-367 (2020). doi: 10.21873/cgp.20195.(*Corresponding author) New!!
  2. Iizasa H, Kim H, Kartika AV, Kanehiro Y, Yoshiyama H. Role of viral and host microRNAs in immune regulation of Epstein-Barr virus-associated diseases.  Front Immunol doi: 10.3389/fimmu.2020.00367. 
  3. Liu G, Ma X, Wang Z, Wakae K, Yuan Y, He Z, Yoshiyama H, Iizasa H, Zhang H, Matsuda M, Sugiyama R, Yuan Z, Muramatsu M, Li L. Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HBV replication by enhancing microRNA-122 processing. J Biol Chem (in press) doi: 10.1074/jbc.RA119.007970. 
  4. Nishikawa J, Iizasa H, Yoshiyama H, Kanami S, Kobayashi Y, Sasaki S, Nakamura M, Sakai K, Suehiro Y, Yamasaki T, Sakaida I. Clinical Importance of Epstein-Barr Virus-associated Gastric Cancer. Cancers (Basel). 10 (6): 167 (2018) . 
  5. Kim H, Iizasa H, Kanehiro Y, Fekadu S, Yoshiyama H. Herpesviral microRNAs for cellular metabolism and immune responses. Front Microbiol 8:1318 (2017).
  6. Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, Iizasa H. Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor.  J Virol 89(5): 2684-2697 (2015).  
  7. Ota H, Sakurai M, Gupta, R, Valente L, Wulff B-E, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K. ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing. Cell 153 (3) : 578-589 (2013).
  8. Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi, M, Irimura T, Hamada J. Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway. Cancer Lett 339 (1) : 82-92 (2013).
  9. Liang S, Furuhashi M, Nakane R, Nakazawa S, Goudarzi H, Hamada J, Iizasa H*. Isolation and characterization of human breast cancer cells with SOX2 promoter activity. Biochem Biophys Res Commun 437 (2) : 205-211 (2013). (*Corresponding author)
  10. Iizasa H*, Nanbo A*, Nishikawa J, Jinushi M, Yoshiyama H. EBV-associated gastric carcinoma. Viruses 4 (12) : 3420-3439 (2012). (*Equal contribution)
  11. Iizasa H, Wulff B-E, Maragkakis M, Megraw M, Hatzigeorgiou A, Iwakiri D, Takada K, Wiedmer A,Showe L,Lieberman P,Nishikura K. Editing of EBV-encoded BART6 microRNAs controls their Dicer targeting and consequently affects viral latency. J Biol Chem285 (43) : 33358-33370 (2010).
  12. Iizasa H, Nishikura K. A new function for the RNA-editing enzyme ADAR1. Nat Immunol 10 (1) : 16-18, (2009).
  13. Kawahara Y, Megraw M, Kreider E, Iizasa H, Valente L, Hatzigeorgiou AG, Nishikura K. Frequency and fate of microRNA editing in human brain. Nucleic Acids Res 36 (16) : 5270-5280 (2008).
  14. Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K. Redirection of silencing targets by adenosine-to-inosine editing of miRNAs. Science 315 (5815) : 1137-1140 (2007).
  15. Iizasa H, Yoneyama H, Mukaida N, Katakoka Y, Naito M, Yoshida N, Nakashima E, Matsushima K. Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with Th2 cytokine production. J Immunol 174 (6 ) : 3273-3280 (2005).
  16. Asashima T, Iizasa H, Terasaki T, Nakashima E. Rat brain pericyte cell lines expressing beta2-adrenergic receptor, angiotensin II receptor type 1A, klotho, and CXCR4 mRNAs despite having endothelial cell markers. J Cell Physiol 197 (1) : 69-76 (2003).
  17. Iizasa H, Genda N, Kitano T, Tomita M, Nishihara K, Hayashi M, Nakamura K, Kobayashi S, Nakashima E. Altered expression and function of P-glycoprotein in dextran sodium sulfate-induced colitis in mice. J Pharm Sci 92 (11) : 569-576 (2003).
  18. Kitano T, Iizasa H, Terasaki T, Asashima T, Matsunaga N, Utoguchi N, Watanabe Y, Obinata M, Ueda M, Nakashima E. Polarized glucose transporters and mRNA expression properties in newly developed rat syncytiotrophoblast cell lines, TR-TBTs. J Cell Physiol 193 (2) : 208-218 (2002).
  19. Asashima T, Iizasa H, Terasaki T, Hosoya K, Tetsuka K, Ueda M, Obinata M, Nakashima E. Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor-β1 and β-glycerophosphate. Eur J Cell Biol 81 (3) : 145-152 (2002).
  20. Kawabata K, Ujikawa M, Egawa T, Kawamoto H, Tachibana K, Iizasa H, Katsura Y, Kishimoto T, Nagasawa T. A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc Natl Acad Sci U S A 96(10): 5663-5667 (1999).
  21. Tachibana K, Hirota S*, Iizasa H*, Yoshida H*, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, Kishimoto T, Nagasawa T. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393 (6685): 591-594 (1998). (*Equal contribution)
  22. Tachibana K, Nakajima T, Sato A, Igarashi K, Shida H, Iizasa H, Yoshida N, Yoshie O, Kishimoto T, Nagasawa T. CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry. J Exp Med 185(10): 1865-1870 (1997).
  23. Kuno K, Iizasa H, Ohno S, Matsushima K. The exon/intron organization and chromosomal mapping of the mouse ADAMTS-1 gene encoding an ADAM family protein with TSP motifs. Genomics46(3): 466-471 (1997).
  24. Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O, Matsushima K, Yoshida N, Springer TA, Kishimoto T. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A 93(25): 14726-14729 (1996).

  Main Books (English)　

  1. Thirion M, Kanda T, Murakami Y, Ochiya T, Iizasa H*. “MicroRNAs and oncogenic human viruses.” MicroRNAs: Key Regulators of Oncogenesis. (Ed. Sadegh Babashah) p155-182, Springer, 2014.(*Corresponding author)
  2. Valente L, Kawahara Y, Zinshteyn B, Iizasa H, Nishikura K. Post-transcriptional gene regulation by an Editor: ADAR and its role in RNA Editing. Post-transcriptional gene regulation: RNA processing in eukaryotes. (Ed. Jane Y.Wu) p41-82 Wiley-VCH Verlag GmbH, 2013.
  3. Iizasa H, Matsushima K. IL-8. Academic Press Cytokine Reference. (Ed. Oppenheim JJ, Feldmann M, Durum SK, Hirano T, Vilcek J, Nicola NA) p1061-1067, Academic Press, 2000.

  Main Patent

  1. IIZASA Hisashi, HATTORI Kenji, NAKASHIMA Emi, TERASAKI Tetsuya, OBINATA Masuo. Immortalized vascular adventital cell line. EU Patent, EP 1 256 625 B1, 2010.