Publications (2013- )


  1. Noda Y, Okada S, Suzuki T. Regulation of A-to-I RNA editing and stop codon recoding to control selenoprotein expression during skeletal myogenesis. Nat Commun. 13(1):2503 (2022). doi: 10.1038/s41467-022-30181-2. (IF: 14.919) New !!


  1. Heawchaiyaphum C, Pientong C, Yoshiyama HIizasa H, Panthong W, Ekalaksananan T. General features and novel gene signatures that identify Epstein-Barr virus-associated epithelial cancers. Cancers (Basel) 14(1): 31 (IF: 6.639) 
  2. Fekadu S#, Kanehiro Y#, Kartika AV, Hamada K, Sakurai N, Mizote T, Akada J, Yamaoka Y, Iizasa H*, Yoshiyama H*. Gastric epithelial attachment of Helicobacter pylori induces EphA2 and NMHC-IIA receptors for Epstein-Barr virus. Cancer Sci 112(11): 4799-4811 (2021) doi: 10.1111/cas.15121. (# Equal contribution, * Corresponding author) (IF: 6.716) 
  3. Li H#, Wang Z#, Liang S#, Liu Q, Wang P, Cai L, Wang R. Radiation induces epithelial to mesenchymal transition via upregulation of PD-L1 in nasopharyngeal carcinoma cell. Trans Cancer Res 10(1): 372-381 (2021) # Equal contribution doi: 10.21037/tcr-20-1899. (IF: 1.07) 
  4. Li H#, Liu Q#, Liang S#, Yao P, Lv J, Wang G, Tang R, Zhao T, Li J, Xu L, Ma L, Wang R. Circulating tumor cells and neutrophil-lymphocyte ratio are predictive markers for metastatic colorectal cancer patients.  Trans Cancer Res 10(1): 288-297 (2021) # Equal contribution doi: 10.21037/tcr-20-2032. (IF: 1.07) 
  5. Kang Y, Ding D, Iizasa H*. Adenosine to Inosine RNA Editing Enzyme ADAR and microRNAs. Methods Mol Biol 2181: 83-95 (2021). (*Corresponding author) 


  1. Yu F *, Lu Y, Li Y, Uchio Y, Pangnguriseng UA, Kartika AV, Iizasa H, Yoshiyama*, Loh KS. Epstein-Barr virus infection of pseudostratified nasopharyngeal epithelium disrupts epithelial integrity. Cancers (Basel) 12(9): 2722 (2020). (*Corresponding author) doi: 10.3390/cancers12092722. (IF: 6.126) 
  2. Richardo T, Prattapong P, Ngernsombat C, Wisetyaningsih N, Iizasa H, Yoshiyama H*, Janvilisri T*. Epstein-Barr virus mediated signaling in nasopharyngeal carcinogenesis.  Cancers (Basel) 12(9) :2441 (2020).  (*Corresponding author) doi: 10.3390/cancers12092441. (IF: 6.126) 
  3. Liu Q#, Fang S#, Liang S#, Lv J, Wang G, Tang R, Ji X, Zhao T, Li J, Xu L, Ma L, Wang R, Li H. The prognostic role of a combined fibrinogen and inflammation-based index in patients with metastatic breast cancer. Transl Cancer Res 9(11): 7065-7078 (2020). # Equal contribution doi: 10.21037/tcr-20-2157. (IF: 0.986) 
  4. Sun Y, Chen X, Zhou Y, Qiu S, Wu Y, Xie M, Zhu G, Liang S, Li H, Zhou D, Ju Z, Wang F, Han F, Wang Z, Wang R. Metformin reverses the drug resistance of cisplatin in irradiated CNE-1 human nasopharyngeal carcinoma cells through PECAM-1 mediated MRPs down-regulation. Int J Med Sci 7(16): 2416–2426 (2020).  doi: 10.7150/ijms.48635. (IF: 2.370) 
  5. Liang S, Takahashi H, Hirose T, Kuramitsu Y, Hatakeyama S, Wang R, Yoshiyama H, Hamada J*, Iizasa H*. NONO is a negative regulator of SOX2 promoter. Cancer Genom Proteom 17(4):359-367 (2020). doi: 10.21873/cgp.20195. (*Corresponding author) (IF: 3.280)
  6. Kartika AV, Iizasa H, Ding D, Kanehiro Y, Tajima Y, Kaji S, Yanai H*, Yoshiyama H*. Application of biopsy samples used for Helicobacter pylori urease test to predict Epstein-Barr virus-associated cancer. Microorganisms 8(6):923 (2020) . doi:10.3390/microorganisms8060923. (*Corresponding author) (IF: 4.152)
  7. Heawchaiyaphum C, Iizasa H, Ekalaksananan T, Burassakarn A, Kiyono T, Kanehiro Y, Yoshiyama H*, Pientong C*. Epstein-Barr virus infection of oral squamous cells. Microorganisms 8(3):419 (2020). doi:10.3390/microorganisms8030419. (*Corresponding author) (IF: 4.152)
  8. Yoshiyama H, Ueda K, Komano J, Iizasa H. Editorial Infection-Associated Cancers.  J Oncol 2020: 4979131 (2020).  doi: 10.1155/2020/4979131. (IF: 2.206)
  9. Sakata K, Maeda K, Sakurai N, Liang S, Nakazawa S, Yanagihara K, Kubo T, Yoshiyama H, Kitagawa Y, Hamada J*, Iizasa H*. ADAR2 regulates malignant behavior in mesothelioma cell lines independent of RNA-editing activity. Anticancer Res 40(3):1307-1314 (2020). doi:10.21873/anticancers.14072. (*Corresponding author) (IF: 1.994)
  10. Iizasa H, Kim H, Kartika AV, Kanehiro Y, Yoshiyama H*.  Role of viral and host microRNAs in immune regulation of Epstein-Barr virus-associated diseases. Front Immunol 11:367 (2020). doi: 10.3389/fimmu.2020.00367. (*Corresponding author) (IF: 5.085)
  11. Liu M, Wang R, Sun X, Liu Y, Wang Z, Yan J, Kong X, Liang S, Liu Q, Zhao T, Ji X, Wang G, Lv W, Li H, Sun M. Prognostic significance of PD-L1 expression on cell-surface vimentin-positive circulating tumor cells in gastric cancer patients. Mol Oncol 14(4):865-881 (2020). doi: 10.1002/1878-0261.12643. (IF: 6.574)
  12. Muchtar A, Kartika V, Ding D, Kang Y, Nagoshi K, Kanehiro Y, Iizasa H, Yoshiyama H*. Comprehensive prevention of hepatitis B virus to reduce primary liver cancer. Shimane J Med Sci 37(1): 13-20 (2020).  (*Corresponding author) 


  1. Kim HIizasa HKanehiro YFekadu SYoshiyama H*. Herpesviral microRNAs for cellular metabolism and immune responses. Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms. (Ed. Arleevskaya MI, Aminov R, Brooks WH, Manukyan G, Renaudineau Y, eds) Lausanne: Frontiers Media SA. doi: 10.3389/978-2-88945-941-4, ISBN: 978-2-88945-941-4 (2019). (*Corresponding author) 
  2. Kim HBurassakarn AKang YIizasa HYoshiyama H. A single nucleotide polymorphism in BART promoter region of Epstein-Barr virus isolated from nasopharyngeal cancer cells. Biochem Biophys Res Commun 520:373-378 (2019). doi: 10.1016/j.bbrc.2019.10.028.  (IF: 2.985)
  3. Yanagi A, Nishikawa J, Shimokuri K, Shuto T, Takagi T, Takagi F, Kobayashi Y, Yamamoto M, Miura O, Yanai H, Suehiro Y,Yamasaki T, Yoshiyama H, Isao S. Clinicopathologic Characteristics of Epstein-Barr Virus-associated Gastric Cancer over the Past Decade in Japan. Microorganisms 7(9). pii: E305 (2019). doi: 10.3390/microorganisms7090305. (IF: 4.152)
  4. Liu G, Ma X, Wang Z, Wakae K, Yuan Y, He Z, Yoshiyama H, Iizasa H, Zhang H, Matsuda M, Sugiyama R, Yuan Z, Muramatsu M, Li L. Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HBV replication by enhancing microRNA-122 processing. J Biol Chem 294:14043-14054 (2019). doi: 10.1074/jbc.RA119.007970. (IF: 4.238)
  5. Wang Z, Liu G, Mao J, Xie M, Zhao M, Guo X, Liang S, Li H, Li X, Wang R. IGF-1R inhibition suppresses cell proliferation and increases radiosensitivity in nasopharyngeal carcinoma cells. Mediat Inflamm 2019:1-9 (2019). doi: 10.1155/2019/5497467. (IF: 3.360)
  6. Yanai H, Iizasa H, Chihara D, Murakami T, Nishikawa J, Yoshiyama H. Epstein-Barr virus detection using gastric biopsy specimens after rapid urease test for Helicobacter pylori: a preliminary experience. Endosc Int Open 07:E431-E432 (2019). doi: 10.1055/a-0859-7233.
  7. Sasaki S, NishikawaJ, Iizasa H, Yoshiyama H, Yanagihara M, Shuto T, Shimokuri K, Kanda T, Sakai K, Suehiro Y, Yamasaki T, Sakaida I. EBV-associated gastric cancer evades T cell immunity by PD-1 / PD-L1 interactions. Gastric Cancer 22:486-496 (2019). doi: 10.1007/s10120-018-0880-4. (IF: 7.088)
  8. Nakazawa S, Sakata KI, Liang S, Yoshikawa K, Iizasa H, Tada M, Hamada JI, Kashiwazaki H, Kitagawa Y, Yamazaki Y. Dominant-negative p53 mutant R248Q increases the motile and invasive activities of oral squamous cell carcinoma cells. Biomed Res 40(1):37-49 (2019). doi: 10.2220/biomedres.40.37. (IF: 1.429)


  1. Ichikawa T, Okuno Y, Sato Y, Toshima F, Yoshiyama H, Kanda T, Kimura H, Murata T. Regulation of EBV lifecycle and cell proliferation by histone H3K27 methyltransferase, EZH2, in Akata cells. mSphare 3(6): pii e00478-18 (2018). doi: 10.1128/mSphere.00478-18. (IF: 4.447)
  2. Kanehiro YStudies on APOBEC-induced mitochondrial dysfunction in EB virus-infected gastric cancer (2017 Young Researcher Award in Shimane University).Valuable Research Works of Shimane University (Introduction of characteristic research works of Shimane University), 12: 32(2018)
  3. Yu F, Lu Y, Tay JK, Yoshiyama H*, Loh KS. Establishment of EBV latency in nasopharyngeal tumor epithelial cells by in vivo cell-mediated transfer infection. Otorhinolaryngol Head Neck Surg 3(3): 1-7 (2018). doi: 10.15761/OHNS.1000174. (*Corresponding author)
  4. Kanehiro Y, Tomioka H,  Pieters J, Tatano Y, Kim H, Iizasa H, Yoshiyama H*. Identification of novel mycobacterial inhibitors against mycobacterial protein kinase G. Front Microbiol 9:1517 (2018). doi: 10.3389/fmicb.2018.01517. (*Corresponding author)  (IF: 4.259)
  5. Nishikawa J, Iizasa HYoshiyama H, Kanami S, Kobayashi Y, Sasaki S, Nakamura M, Sakai K, Suehiro Y, Yamasaki T, Sakaida I. Clinical importance of Epstein-Barr virus-associated gastric cancer. Cancers (Basel) 10 (6): 167 (2018). doi: 10.3390/cancers10060167. (IF: 6.162)
  6. Deyno S, Fekadu S, Seyfe S. Prevalence and antimicrobial resistance of coagulase negative staphylococci clinical isolates from Ethiopia: a meta-analysis. BMC Microbiol 18:43 (2018). doi: 10.1186/s12866-018-1186-6. (IF: 3.287)
  7. Nanbo A, Ohashi M, Yoshiyama H, Ohba Y. The role of transforming growth factor-beta in cell to cell contact mediated Epstein-Barr virus transmission. Front Microbiol 9:984 (2018). doi: 10.3389/ fmicb. 2018.00984.  (IF: 4.259)


  1. Yu F, Lu Y, Tao L, Jiang YY, Lin DC, Wang L, Petersson F, Yoshiyama H, Koeffler HP, Goh BC, Loh S. Non-malignant epithelial cells preferentially proliferate from nasopharyngeal carcinoma biopsy cultured under conditionally reprogrammed conditions. Sci Rep 7: 17539 (2017). doi: 10.1038/s41598 -017-17628-z.  (IF: 4.122)
  2. Deyno S, Fekadu S, Astatkie A. Resistance of Staphylococcus aureus to antimicrobial agents in Ethiopia: a meta- analysis. Antimicrob Resist Infect Control
 6:85 (2017). doi: 10.1186/s13756 -017-0243-7.  (IF: 3.568)
  3. Nishikawa J, Iizasa H, Yoshiyama Y, Nakamura M, Saito M, Sasaki S, Shimokuri K, Yanagihara M, Sakai K, Suehiro Y, Suehiro Y, Yamasaki T, Sakaida I. The role of epigenetic regulation in Epstein-Barr virus-associated gastric cancer. Int J Mol Sci 18 (8): E1606 (2017). doi:10.3390/ijms18081606. (IF: 3.687)
  4. Kim H, Iizasa H, Kanehiro Y, Fekadu S, Yoshiyama H*. Herpesviral microRNAs for cellular metabolism and immune responses. Front Microbiol 8:1318 (2017). doi: 10.3389/ fmicb. 2017.01318. (*Corresponding author)  (IF: 4.019)
  5. Kawaguchi Y, Nariki H, Kawamoto N, Kanehiro Y, Miyazaki S, Suzuki M, Magari M, Tokumitsu H, Kanayama N. SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus. Biochem Biophys Res Commun 485 (2) : 261-266 (2017). (IF: 2.559)
  6. Torii Y, Kawada JI, Murata T, Yoshiyama H, Kimura H, Ito Y. Epstein-Barr  virus infection-induced inflammasome activation in human monocytes. PLoS One 12(4): e0175053 (2017). (IF: 2.776)


  1. Nanbo A, Kachi K, Yoshiyama H, Ohba Y. Epstein-Barr virus exploits host endocytic machinery for cell-to-cell viral transmission rather than a virological synapse. J Gen Virol 97(11):2989-3006 (2016).  doi: 10.1099/jgv.0.000605. (IF: 2.838)
  2. Murata T, Noda C, Narina Y, Watanabe T, Yoshida M, Ashio K, Sato Y, Goshima F, Kanda T, Yoshiyama H, Tsurumi T, Kimura H. Induction of Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1) by transcription factor activating protein 2 (AP-2) and early B cell factor (EBF). J Virol 90:3873-3889 (2016). (IF: 4.663)
  3. Li H, Zhao T, Ji X, Liang S, Wang Z, Yang Y, Yin J, Wang R.Hyperfibrinogenemia predicts poor prognosis in patients with advanced biliary tract cancer.Tumor Biol 37(3):3535-3542 (2016). doi: 10.1007/s13277-015-4184-6. (IF: 3.650)
  4. Sarlak G, Htoo HH, Hernandez J-F, Rizzino A, Iizasa H, Konietzko U, Checler F, Postina R, Song W, Bruno V. Sox2 functionally interacts with beta APP, the beta APP intracellular domain and ADAM10 at a transcriptional level in human cells. Neuroscience 312 : 153-164 (2016). (IF: 3.277)


  1. Iizasa H, Ishihara S, Richardo T, Kanehiro Y, Yoshiyama H*. Dysbiotic infection in the stomach. World J Gastroenterol 21 (40): 11450-11457 (2015). (*Corresponding author) (IF: 2.787)
  2. Kataoka S, Muramatsu H, Okuno Y, Hayashi Y, Mizoguchi Y, Tsumura M, Okada S, Kobayashi M, Sano C, Sato H, Oh-Iwa I, Ito M, Kojima D, Hama A, Takahashi Y, Kojima S. Extrapulmonary tuberculosis mimicking Mendelian susceptibility to mycobacterial disease in a patient with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. J Allergy Clin Immunol 2015 Aug 1. pii: S0091-6749(15)00881-7. doi: 10.1016/ j.jaci. 2015.06.028. (IF: 12.485)
  3. Tatano Y, Kanehiro Y, Sano C, Shimizu T, Tomioka H. ATP exhibits antimicrobial action by inhibiting bacterial utilization of ferric ion. Sci Rep 5: 8610 (2015). (IF: 5.228)
  4. Kanda T, Miyata M, Kano M, Kondo S, Yoshizaki T, Iizasa H. Clustered microRNAs of the Epstein-Barr virus cooperatively downregulate an epithelial cell-specific metastasis suppressor.  J Virol 89 (5): 2684-2697 (2015).  (IF: 4.606)
  5. Kohayagawa Y, Ishitobi N, Yamamori Y, Wakuri M, Sano C, Tominaga K, Ikebe T. Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. J Infect Chemother 21 (2): 144-147 (2015). (IF: 1.425)


  1. Nishikawa J, Yoshiyama H, Iizasa H, Kanehiro Y, Nakamura M, Nishimura J, Saito M, Okamoto T, Sakai K, Suehiro Y, Yamasaki T, Oga A, Yanai H, Sakaida I. Epstein-Barr virus in gastric carcinoma. Cancers 6(4): 2259-2274 (2014). (IF: 5.326)
  2. Gallat FX, Matsugaki N, Coussens NP, Yagi KJ, Boudes M, Higashi T, Tsuji D, Tatano Y, Suzuki M, Suzuki M, Mizohata E, Tono K, Kameshima T, Park J, Song C, Hatsui T, Yabashi M, Nahgo E, Itoh K, Coulibaly F, Tobe S, Ramaswamy S, Stay B, Iwata S, Chavas LM. In vivo crystallography at X-ray free-electron lasers: the next generation of structural biology? Philos Trans R Soc Lond B Biol Sci 369 (1647): 20130497 (2014). (IF: 7.055)
  3. Tatano Y, Shimizu T, Tomioka H. Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis while upregulating Th17 polarization. Sci Rep 4: 4146 (2014). (IF: 5.578)
  4. Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E. Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells. Biol Pharm Bull 37 (4): 688-693 (2014). (IF: 1.828)
  5. Okamoto T, Hayashi Y, Yanai H, Nishikawa J, Nakazawa T, Iizasa H, Jinushi M, Sakaida I, Yoshiyama H*. Colonization of an acid resistant Kingella denitrificans in the stomach may contribute to gastric dysbiosis by Helicobacter pylori. J Infect Chemother 20 (3): 169-174 (2014). (*Corresponding author) (IF: 1.486)
  6. Takeda S, Kanbayashi D, Kurata T, Yoshiyama H, Komano J.Enhanced susceptibility of B lymphoma cells to measles virus by EBV type III latency that up-regulates CD150/SLAM. Cancer Sci 105 (2): 211-218 (2014). (IF: 3.523)
  7. Thirion M, Kanda T, Murakami Y, Ochiya T, Iizasa H*. “MicroRNAs and oncogenic human viruses.”MicroRNAs: Key Regulators of Oncogenesis. (Ed. Sadegh Babashah) Springer, 155-182 (2014). (*Corresponding author)

◎  2013

  1. Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M. TIM-4 Glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance. Immunity 39 (6): 1070-1081 (2013). (IF: 19.748)
  2. Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi, M, Irimura T, Hamada J. Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1 alpha-MUC1 pathway. Cancer Lett 339 (1): 82-92 (2013). (IF: 5.992)
  3. Liang S, Furuhashi M, Nakane R, Nakazawa S, Goudarzi H, Hamada J*, Iizasa H*. Isolation and characterization of human breast cancer cells with SOX2 promoter activity. Biochem Biophys Res Commun 437 (2): 205-211 (2013). (*Corresponding author) (IF: 2.297)
  4. Ota H, Sakurai M, Gupta, R, Valente L, Wulff B-E, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K. ADAR1 forms a complex with dicer to promote microRNA processing and RNA-induced gene silencing. Cell 153 (3): 578-589 (2013). (IF: 33.116)
  5. Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E. Estrogen receptor alpha induction by mitoxantrone increases abcg2 expression in placental trophoblast cells. J Pharm Sci 102 (9): 3364-3372 (2013). (IF: 2.590)
  6. Goudarzi H,Hida Y, Takano H, Teramae H, Iizasa H, Hamada J. Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma. Biomed Res 34 (1): 13-21 (2013). (IF: 1.138)
  7. Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H. Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveolae-dependent endocytosis and promote phenotypic modulation in the target cells. J Virol 87(18): 3420-3439, (2013). (IF: 4.648)
  8. Jinushi M, Yagita H, Yoshiyama H, Tahara H. Putting the brake on anticancer therapies: negative regulation of innate immune pathways by tumor-associated myeloid cells. Trends Mol Med 19 (9): 536-545 (2013). (IF: 10.110)
  9. Baghdadi M, Yoshiyama H, Akiba Hi, Yagita H, Akita H, Jinushi M. Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas. Cancer Immunol Immunother 62(4): 629-637 (2013). (IF: 3.943) 
  10. Valente L, Kawahara Y, Zinshteyn B, Iizasa H, Nishikura K. Post-transcriptional gene regulation by an Editor: ADAR and its role in RNA Editing. Post-transcriptional gene regulation: RNA processing in eukaryotes. (Ed. Jane Y.Wu) Wiley-VCH Verlag GmbH, 41-82 (2013).