Hironori Yoshiyama PhD.


From Yamaguchi Prefecture

Graduated from Yamaguchi University

Doctor of medical science

Specializes in EB virus and Helicobacter pylori

Hobby is any type of music

yosiyama(A) med.shimane-u.ac.jp   (A) change to @


Main Papers

  1. Nishikawa J, Yoshiyama H, Iizasa H, Kanehiro Y, Nakamura M, Nishimura J, Saito M, Okamoto T, Sakai K, Suehiro Y, Yamasaki T, Oga A, Yanai H, Sakaida I. Epstein-Barr virus in gastric carcinoma. Cancers 6: 2259-2274, 2014. “New”
  2. OkamotoT, Hayashi Y, Mizuno H, Yanai H, Nishikawa J, Nakazawa T, Iizasa H, Jinushi M, Sakaida I, Yoshiyama H. Colonization of an acid resistant Kingella denitrificans in the stomach may contribute to gastric dysbiosis by Helicobacter pylori. J Infect Chemother 20: 169-174, 2014.
  3. Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M. TIM-4 glycoprotein-mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance. Immunity39: 1070-1081. 2013.
  4. Nanbo A, Kawanishi E, Yoshida R, Yoshiyama H. Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveolae-dependent endocytosis and promote phenotypic modulation in the target cells. J Virol 87: 10334-10347, 2013.
  5. Iizasa H, Nanbo A, Nishikawa J, Jinushi M, Yoshiyama H. EBV-associated gastric carcinoma. Viruses 4: 3420-3439, 2012.
  6. Chiba S, Baghdadi M, Akiba H, Kinoshita I, Yoshiyama H, Hirashima M, Dosaka-Akita H, Uede T, Takaoka A, Yagita H, Jinushi M.Dendritic cell-derived TIM-3 is a universal repressor of nucleic acids-mediated antitumor innate immune responses.Nat Immunol13: 832–842, 2012.
  7. Jinushi M, Chiba S, Baghdadi M, Kinoshita I, Dosaka-Akita H, Ito K, Yoshiyama H, Yagita H, Uede T, Takaoka A. ATM-mediated DNA damage signals suppress antitumor immunity by integrin-αvβ3-dependent mechanisms. Cancer Res72: 56-65, 2012.
  8. Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H. Tumor-associated macrophages regulate tumorigenicity and anti-cancer drug responses of cancer stem/initiating cells. Proc Natl Acad Sci USA108: 12425-12430, 2011.
  9. Nanbo A,Yoshiyama H, Takada K. Epstein-Barr virus-encoded poly(A) RNA confers resistance to apoptosis mediated through Fas by blocking the PKR pathway in human epithelial intestine 407 cell. J Virol 79: 12280-12285, 2005.
  10. Okamoto T, Yoshiyama H, Nakazawa T, Park ID, Chang MW, Yanai H, Okita K, Shirai M. A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori. J Antimicrob Chemother 50: 849-856, 2002.
  11. Yoshiyama H, Nakazawa T. A unique mechanism of Helicobacter pylori for colonizing the gastric mucus. Microb Infect 2: 1-6, 2000.
  12. Yoshiyama H, Nakamura H, Kimoto M, Okita K and Nakazawa T. Chemotaxis and motility of Helicobacter pylori in a viscous environment. J Gastroenterol 34(Suppl. 11): 18-23, 1999.
  13. Yanai H, Murakami T, Yoshiyama H, Takeuchi H, Nishikawa J, Nakamura H, Tada M, Okita K, Miura O, Shimizu N and Takada K. Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis. J Clin Gastroenterol 29: 39-43, 1999.
  14. Nakamura H, Yoshiyama H, Takeuchi H, Mizote T, Okita K and Nakazawa T. Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment. Inf Immun 66: 4832-4837, 1998.
  15. Yoshiyama H, Imai S, Shimizu N, Takada K. Epstein-Barr virus infection to human gastric carcinoma cells : Implication of the existence of a new virus receptor different from CD21. J Virol 71: 5688-5691, 1997.
  16. Mizote T, Yoshiyama H, Nakazawa T. Urease-independent chemotactic response to urea, urease inhibitors, and sodium bicarbonate of Helicobacter pylori. Inf Immun 65: 1519-1521, 1997.
  17. Shimizu N, Yoshiyama H, Takada K. Clonal propagation of Epstein-Barr virus (EBV) recombinants in EBV-negative Akata cells. J Virol 70: 7260-7263, 1996.
  18. Yoshiyama H, Shimizu N, Takada K. Persistent Epstein-Barr virus infection in a human T-cell line: Unique program of latent virus expression. EMBO J 14: 3706-3711, 1995.
  19. Yoshiyama H, Mo HM, Moore JP, Ho DD. Characterization of mutants of human immunodeficiency virus type1 that have escaped neutralization by a monoclonal antibody to the gp120 V2 loop. J Virol 68: 974-978, 1994.
  20. Kang CY, Nara P, Chamat S, Caralli V, Chen A, Nguyen ML, Yoshiyama H, Morrow WJW, Ho DD, Köler H. Anti-idiotype monoclonal antibody elicits broadly neutralizing anti-gp120 antibodies in monkeys. Proc Natl Acad Sci USA 89: 2546-2550, 1992.
  21. Yoshiyama H, Suzuki E, Yoshida T, Kajii T, Yamamoto N. Role of human herpesvirus 6 infection in infants with exanthema subitum. Pediatr Infect Dis J 9: 71-74, 1990.
  22. Yoshiyama H, Kobayashi S, Tanabe A, Kajii T, Yamamoto N. Detection of human immunodeficiency virus (HIV) in cultures of lymphocytes from HIV-seropositive persons with special reference to an enzyme immunoassay. J Infect 19: 143-151, 1989.
  23. Yoshiyama H, Koyanagi Y, Nakashima H, Ishihara T, Uchino F, Harada S, Okino F, Kajii T, Yamamoto N. Detection and isolation of an acquired immune deficiency syndrome (AIDS)-related virus (HTLV III/LAV) from a japanese boy with AIDS-related complex. Jpn J Cancer Res (GANN) 77: 16-20, 1986.

Main Books


  1. Yanai H, Shimizu N, Mizugaki Y, Nishikawa J, Yoshiyama H, Tada M, Okita K and Takada K. The gastric mucosa surrounding Epstein-Barr virus-associated gastric cancers. pp103-108 (Osato T, Takada K and Tokunaga M, Gann Monograph on Cancer Research No. 45; Epstein-Barr virus and human cancer. Japanese Cancer Association, Tokyo) 1998.
  2. Ho DD, Yoshiyama H, Mohri H, Daar ES, Cao Y. Quantitation on of HIV-1: significance in pathogenesis and therapy. In: Andrieu JM. ed. Viral Quantitation in HIV Infection. John Libbey Eurotext, Paris, 3-7, 1991.

  Editorial Board Member

  1. American Journal of Infectious Diseases and Microbiology
  2. Journal of Nasopharyngeal Carcinoma